2Y66

New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation

Summary for 2Y66

Entry DOI	10.2210/pdb2y66/pdb
Related	1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 2X5O 2Y1O 2Y67 2Y68 3UAG 4UAG
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (2R)-2-[[3-[[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl]phenyl]carbonylamino]pentanedioic acid, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	atp-binding, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase, nucleotide-binding, peptidoglycan synthesis, uma
Biological source	ESCHERICHIA COLI
Cellular location	Cytoplasm: P14900
Total number of polymer chains	1
Total formula weight	48753.59
Authors	Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Muller-Premru, M.,Zega, A.,Gobec, S.,Peterlin-Masic, L.,Kikelj, D. (deposition date: 2011-01-20, release date: 2011-10-19, Last modification date: 2023-12-20)
Primary citation	Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Premru, M.M.,Zega, A.,Gobec, S.,Masic, L.P.,Kikelj, D. New 5-Benzylidenethiazolidin-4-One Inhibitors of Bacterial Murd Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation. Eur.J.Med.Chem, 46:5512-, 2011 Cited by PubMed: 21963114 DOI: 10.1016/J.EJMECH.2011.09.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation