2Y37

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

Summary for 2Y37

• Entry DOI: 10.2210/pdb2y37/pdb
• Related: 1DD7 1DF1 1DWV 1DWW 1DWX 1JWJ 1JWK 1M8D 1M8E 1M8H 1M8I 1M9T 1N2N 1NOC 1NOD 1NOS 1QOM 1QW4 1QW5 1R35 1VAF 2BHJ 2NOD 2NOS 3NOD
• Descriptor: NITRIC OXIDE SYNTHASE, INDUCIBLE, SULFATE ION, GLYCEROL, ... (7 entities in total)
• Functional Keywords: drug design, oxidoreductase
• Biological source: MUS MUSCULUS (HOUSE MOUSE)
• Total number of polymer chains: 2
• Total formula weight: 103003.26

Authors

Cheshire, D.R.,Andrews, G.,Beaton, H.G.,Birkinshaw, T.N.,Boughton-Smith, N.,Connolly, S.,Cook, T.R.,Cooper, A.,Cooper, S.L.,Cox, D.,Dixon, J.,Gensmantel, N.,Hamley, P.J.,Harrison, R.,Hartopp, P.,Kack, H.,Luker, T.,Mete, A.,Millichip, I.,Nicholls, D.J.,Pimm, A.D.,St-Gallay, S.A.,Wallace, A.V. (deposition date: 2010-12-19, release date: 2011-04-13, Last modification date: 2018-01-17)

• Primary citation: Cheshire, D.R.,Berg, A.,Andersson, G.M.,Andrews, G.,Beaton, H.G.,Birkinshaw, T.N.,Boughton-Smith, N.,Connolly, S.,Cook, T.R.,Cooper, A.,Cooper, S.L.,Cox, D.,Dixon, J.,Gensmantel, N.,Hamley, P.J.,Harrison, R.,Hartopp, P.,Kack, H.,Leeson, P.D.,Luker, T.,Mete, A.,Millichip, I.,Nicholls, D.J.,Pimm, A.D.,St-Gallay, S.A.,Wallace, A.V.; The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).; Bioorg.Med.Chem.Lett., 21:2468-, 2011; PubMed: 21398123; DOI: 10.1016/J.BMCL.2011.02.061

Experimental method

X-RAY DIFFRACTION (2.6 Å)