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2Y1W

CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR

Summary for 2Y1W
Entry DOI10.2210/pdb2y1w/pdb
Related2Y1X
DescriptorHISTONE-ARGININE METHYLTRANSFERASE CARM1, SINEFUNGIN, 2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE, ... (4 entities in total)
Functional Keywordshistone modification, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: Q86X55
Total number of polymer chains4
Total formula weight160971.13
Authors
Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. (deposition date: 2010-12-10, release date: 2011-03-23, Last modification date: 2011-07-13)
Primary citationSack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A.
Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors
Biochem.J., 436:331-, 2011
Cited by
PubMed: 21410432
DOI: 10.1042/BJ20102161
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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