2Y1W
CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE SFG A 1001 |
| Chain | Residue |
| A | TYR150 |
| A | ILE198 |
| A | LEU199 |
| A | GLU215 |
| A | ALA216 |
| A | GLY241 |
| A | LYS242 |
| A | VAL243 |
| A | GLU244 |
| A | GLU258 |
| A | MET269 |
| A | PHE151 |
| A | SER272 |
| A | 8491005 |
| A | HOH2006 |
| A | HOH2014 |
| A | HOH2098 |
| A | HOH2099 |
| A | TYR154 |
| A | GLN160 |
| A | MET163 |
| A | ARG169 |
| A | GLY193 |
| A | CYS194 |
| A | GLY195 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE SFG B 1001 |
| Chain | Residue |
| A | HOH2100 |
| B | TYR150 |
| B | PHE151 |
| B | TYR154 |
| B | GLN160 |
| B | MET163 |
| B | ARG169 |
| B | GLY193 |
| B | CYS194 |
| B | GLY195 |
| B | ILE198 |
| B | LEU199 |
| B | GLU215 |
| B | ALA216 |
| B | GLY241 |
| B | LYS242 |
| B | VAL243 |
| B | GLU244 |
| B | GLU258 |
| B | MET269 |
| B | SER272 |
| B | 8491005 |
| B | HOH2035 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE SFG C 1001 |
| Chain | Residue |
| C | TYR150 |
| C | PHE151 |
| C | TYR154 |
| C | GLN160 |
| C | MET163 |
| C | ARG169 |
| C | GLY193 |
| C | CYS194 |
| C | GLY195 |
| C | ILE198 |
| C | GLU215 |
| C | ALA216 |
| C | GLY241 |
| C | LYS242 |
| C | VAL243 |
| C | GLU244 |
| C | GLU258 |
| C | MET269 |
| C | SER272 |
| C | 8491005 |
| C | HOH2012 |
| C | HOH2036 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE SFG D 1001 |
| Chain | Residue |
| A | HOH2101 |
| A | HOH2102 |
| D | PHE151 |
| D | TYR154 |
| D | GLN160 |
| D | MET163 |
| D | ARG169 |
| D | GLY193 |
| D | CYS194 |
| D | GLY195 |
| D | ILE198 |
| D | LEU199 |
| D | GLU215 |
| D | ALA216 |
| D | GLY241 |
| D | LYS242 |
| D | VAL243 |
| D | GLU244 |
| D | GLU258 |
| D | MET269 |
| D | SER272 |
| D | 8491005 |
| D | HOH2007 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 849 A 1005 |
| Chain | Residue |
| A | PRO259 |
| A | MET260 |
| A | TYR262 |
| A | ASN266 |
| A | GLU267 |
| A | MET269 |
| A | HIS415 |
| A | TRP416 |
| A | ARG446 |
| A | GLN447 |
| A | SFG1001 |
| A | HOH2022 |
| A | SER146 |
| A | GLN149 |
| A | TYR150 |
| A | PHE153 |
| A | TYR154 |
| A | GLU258 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 849 B 1005 |
| Chain | Residue |
| A | HOH2103 |
| B | SER146 |
| B | TYR150 |
| B | PHE153 |
| B | TYR154 |
| B | GLU258 |
| B | PRO259 |
| B | MET260 |
| B | TYR262 |
| B | ASN266 |
| B | GLU267 |
| B | MET269 |
| B | HIS415 |
| B | TRP416 |
| B | ARG446 |
| B | GLN447 |
| B | SFG1001 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 849 C 1005 |
| Chain | Residue |
| C | SER146 |
| C | TYR150 |
| C | PHE153 |
| C | TYR154 |
| C | GLU258 |
| C | PRO259 |
| C | MET260 |
| C | TYR262 |
| C | ASN266 |
| C | GLU267 |
| C | MET269 |
| C | HIS415 |
| C | TRP416 |
| C | ARG446 |
| C | GLN447 |
| C | SFG1001 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 849 D 1005 |
| Chain | Residue |
| A | HOH2104 |
| D | SER146 |
| D | TYR150 |
| D | PHE153 |
| D | TYR154 |
| D | GLU258 |
| D | PRO259 |
| D | MET260 |
| D | TYR262 |
| D | ASN266 |
| D | GLU267 |
| D | HIS415 |
| D | TRP416 |
| D | ARG446 |
| D | GLN447 |
| D | SFG1001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
| Chain | Residue | Details |
| A | GLN160 | |
| B | GLU215 | |
| B | GLU244 | |
| B | SER272 | |
| C | GLN160 | |
| C | ARG169 | |
| C | GLY193 | |
| C | GLU215 | |
| C | GLU244 | |
| C | SER272 | |
| D | GLN160 | |
| A | ARG169 | |
| D | ARG169 | |
| D | GLY193 | |
| D | GLU215 | |
| D | GLU244 | |
| D | SER272 | |
| A | GLY193 | |
| A | GLU215 | |
| A | GLU244 | |
| A | SER272 | |
| B | GLN160 | |
| B | ARG169 | |
| B | GLY193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| A | SER217 | |
| B | SER217 | |
| C | SER217 | |
| D | SER217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
| Chain | Residue | Details |
| A | LYS228 | |
| B | LYS228 | |
| C | LYS228 | |
| D | LYS228 |
