2Y1W

CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	HISTONE-ARGININE METHYLTRANSFERASE CARM1	polymer	348	39479.9	4	UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528)	HOMO SAPIENS (HUMAN)	CARM1, COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1, PROTEIN ARGININE N-METHYLTRANSFERASE 4
2	E, G, I, K (A, B, C, D)	SINEFUNGIN	non-polymer		381.4	4	Chemie (SFG)
3	F, H, J, L (A, B, C, D)	2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE	non-polymer		381.5	4	Chemie (849)
4	M, N, O, P (A, B, C, D)	water	water		18.0	352	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	157919.6
Non-Polymers*	Number of molecules	8
	Total formula weight	3051.5
All*	Total formula weight	160971.1

*Water molecules are not included.