2Y1G

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted FR900098 analogue and manganese.

2Y1G の概要

• エントリーDOI: 10.2210/pdb2y1g/pdb
• 関連するPDBエントリー: 2Y1C 2Y1D 2Y1E 2Y1F
• 分子名称: 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, doxp/mep pathway
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84142.12

構造登録者

Henriksson, L.M.,Larsson, A.M.S.,Bergfors, T.,Bjorkelid, C.,Unge, T.,Mowbray, S.L.,Jones, T.A. (登録日: 2010-12-08, 公開日: 2011-06-29, 最終更新日: 2023-12-20)

• 主引用文献: Andaloussi, M.,Henriksson, L.M.,Wieckowska, A.,Lindh, M.,Bjorkelid, C.,Larsson, A.M.S.,Iyer, H.,Srinivasa, B.R.,Bergfors, T.,Unge, T.,Mowbray, S.L.,Larhed, M.,Jones, T.A.,Karlen, A.; Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase; J.Med.Chem, 54:4964-, 2011; PubMed: 21678907; DOI: 10.1021/JM2000085

実験手法