2XX3

HUMAN THYMIDYLATE KINASE COMPLEXED WITH thymidine butenyl phosphonate monophosphate and ADP

Summary for 2XX3

Entry DOI	10.2210/pdb2xx3/pdb
Related	1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5
Descriptor	THYMIDYLATE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	transferase, acyclic nucleoside phosphonate
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	26881.42
Authors	Caillat, C.,Meyer, P. (deposition date: 2010-11-08, release date: 2011-12-07)
Primary citation	Topalis, D.,Pradere, U.,Roy, V.,Caillat, C.,Azzouzi, A.,Broggi, J.,Snoeck, R.,Andrei, G.,Lin, J.,Eriksson, S.,Alexandre, J.A.C.,El-Amri, C.,Deville-Bonne, D.,Meyer, P.,Balzarini, J.,Agrofoglio, L.A. Novel Antiviral C5-Substituted Pyrimidine Acyclic Nucleoside Phosphonates Selected as Human Thymidylate Kinase Substrates. J.Med.Chem., 54:222-, 2011 Cited by PubMed: 21128666 DOI: 10.1021/JM1011462 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation