2XVD
ephB4 kinase domain inhibitor complex
Summary for 2XVD
Entry DOI | 10.2210/pdb2xvd/pdb |
Related | 2BBA 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F |
Descriptor | EPHRIN TYPE-B RECEPTOR 4, {4-METHYL-3-[(1-METHYLETHYL)(2-{[3-(METHYLSULFONYL)-5-MORPHOLIN-4-YLPHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENYL}METHANOL, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34519.37 |
Authors | Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L. (deposition date: 2010-10-25, release date: 2011-06-08, Last modification date: 2023-12-20) |
Primary citation | Barlaam, B.,Ducray, R.,Lambert-Van Der Brempt, C.,Ple, P.,Bardelle, C.,Brooks, N.,Coleman, T.,Cross, D.,Kettle, J.G.,Read, J. Inhibitors of the Tyrosine Kinase Ephb4. Part 4: Discovery and Optimization of a Benzylic Alcohol Series. Bioorg.Med.Chem.Lett., 21:2207-, 2011 Cited by PubMed: 21441027DOI: 10.1016/J.BMCL.2011.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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