2XTJ
The crystal structure of PCSK9 in complex with 1D05 Fab
Summary for 2XTJ
Entry DOI | 10.2210/pdb2xtj/pdb |
Related | 2W2M 2W2N 2W2O 2W2P 2W2Q |
Descriptor | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05, PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9, ... (8 entities in total) |
Functional Keywords | hydrolase-antibody complex, serine protease, ldl-c, ldlr, egf-a, hypercholesterolemia, hydrolase/antibody |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 6 |
Total formula weight | 96433.25 |
Authors | Di Marco, S.,Volpari, C.,Carfi, A. (deposition date: 2010-10-10, release date: 2010-11-03, Last modification date: 2023-12-20) |
Primary citation | Ni, Y.G.,Di Marco, S.,Condra, J.H.,Peterson, L.B.,Wang, W.,Wang, F.,Pandit, S.,Hammond, H.A.,Rosa, R.,Cummings, R.T.,Wood, D.D.,Liu, X.,Bottomley, M.J.,Shen, X.,Cubbon, R.M.,Wang, S.P.,Johns, D.G.,Volpari, C.,Hamuro, L.,Chin, J.,Huang, L.,Zhao, J.Z.,Vitelli, S.,Haytko, P.,Wisniewski, D.,Mitnaul, L.J.,Sparrow, C.P.,Hubbard, B.,Carfi, A.,Sitlani, A. A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo. J.Lipid Res., 52:78-, 2011 Cited by PubMed: 20959675DOI: 10.1194/JLR.M011445 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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