2XPG

Crystal structure of a MHC class I-peptide complex

Summary for 2XPG

• Entry DOI: 10.2210/pdb2xpg/pdb
• Related: 1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S9W 1S9X 1S9Y 1SYS 1SYV 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZS8 1ZSD 1ZT4 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2ESV 2F74 2F8O 2GJ6 2H26 2HJK 2HJL 2HLA 2J8U 2JCC 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 3HLA
• Descriptor: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-3 ALPHA CHAIN, BETA-2-MICROGLOBULIN, MYELIN PROTEOLIPID PROTEIN, ... (4 entities in total)
• Functional Keywords: immune system, autoimmunity, multiple sclerosis
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Membrane; Single-pass type I membrane protein: P04439; Secreted: P61769; Membrane; Multi-pass membrane protein: P60201
• Total number of polymer chains: 3
• Total formula weight: 44334.06

Authors

McMahon, R.M.,Friis, L.,Siebold, C.,Friese, M.A.,Fugger, L.,Jones, E.Y. (deposition date: 2010-08-26, release date: 2011-04-27, Last modification date: 2024-10-16)

Primary citation

Mcmahon, R.M.,Friis, L.,Siebold, C.,Friese, M.A.,Fugger, L.,Jones, E.Y.
Structure of Hla-A0301 in Complex with a Peptide of Proteolipid Protein: Insights Into the Role of Hla-A Alleles in Susceptibility to Multiple Sclerosis
Acta Crystallogr.,Sect.D, 67:447-, 2011

PubMed Abstract: The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the central nervous system. The KLIETYFSK peptide is a naturally processed epitope of proteolipid protein, a myelin protein and candidate target for immune-mediated myelin destruction in MS. Comparison of the structure of HLA-A3 with that of HLA-A2, an MHC class I molecule which is protective against MS, indicates that both MHC class I molecules present very similar faces for T-cell receptor recognition whilst differing in the specificity of their peptide-binding grooves. These characteristics may underlie the opposing (predisposing versus protective) associations that they exhibit both in humans and in mouse models of MS-like disease. Furthermore, subtle alterations within the peptide-binding groove of HLA-A3 and other A3-like MHC class I molecules, members of the so-called A3 superfamily, may be sufficient to alter their presentation of autoantigen peptides such as KLIETYFSK. This in turn may modulate their contribution to the associated risk of autoimmune disease.

PubMed: 21543847
DOI: 10.1107/S0907444911007888

Experimental method

X-RAY DIFFRACTION (2.6 Å)