2XNY
A fragment of streptococcal M1 protein in complex with human fibrinogen
Summary for 2XNY
| Entry DOI | 10.2210/pdb2xny/pdb |
| Related | 1BBR 1DUG 1FIB 1FIC 1FID 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2FFD 2FIB 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2Y7L 3FIB |
| Descriptor | FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA CHAIN, ... (4 entities in total) |
| Functional Keywords | cell adhesion, virulence factor, streptococcal toxic shock syndrome |
| Biological source | STREPTOCOCCUS PYOGENES More |
| Cellular location | Secreted: P02671 P02675 P02679 Secreted, cell wall; Peptidoglycan-anchor (By similarity): Q48WD8 |
| Total number of polymer chains | 8 |
| Total formula weight | 192453.31 |
| Authors | Macheboeuf, P.,Y Fu, C.,Zinkernagel, A.S.,Johnson, J.E.,Nizet, V.,Ghosh, P. (deposition date: 2010-08-06, release date: 2011-04-13, Last modification date: 2024-10-16) |
| Primary citation | Macheboeuf, P.,Buffalo, C.,Fu, C.Y.,Zinkernagel, A.S.,Cole, J.N.,Johnson, J.E.,Nizet, V.,Nizet, V.,Ghosh, P. Streptococcal M1 Protein Constructs a Pathological Host Fibrinogen Network Nature, 472:64-, 2011 Cited by PubMed Abstract: M1 protein, a major virulence factor of the leading invasive strain of group A Streptococcus, is sufficient to induce toxic-shock-like vascular leakage and tissue injury. These events are triggered by the formation of a complex between M1 and fibrinogen that, unlike M1 or fibrinogen alone, leads to neutrophil activation. Here we provide a structural explanation for the pathological properties of the complex formed between streptococcal M1 and human fibrinogen. A conformationally dynamic coiled-coil dimer of M1 was found to organize four fibrinogen molecules into a specific cross-like pattern. This pattern supported the construction of a supramolecular network that was required for neutrophil activation but was distinct from a fibrin clot. Disruption of this network into other supramolecular assemblies was not tolerated. These results have bearing on the pathophysiology of streptococcal toxic shock. PubMed: 21475196DOI: 10.1038/NATURE09967 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (7.5 Å) |
Structure validation
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