2VR3

Structural and Biochemical Characterization of Fibrinogen binding to ClfA from Staphylocccus aureus

Summary for 2VR3

Entry DOI	10.2210/pdb2vr3/pdb
Related	1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2FFD 2FIB 3FIB
Descriptor	CLUMPING FACTOR A, FIBRINOGEN GAMMA-CHAIN (3 entities in total)
Functional Keywords	platelet aggregation, peptidoglycan-anchor, cell adhesion, staphylococcus aureus, fibrinogen gamma-chain, secreted, cell wall, virulence, clumping factor
Biological source	STAPHYLOCOCCUS AUREUS More
Cellular location	Secreted, cell wall; Peptidoglycan-anchor (Potential): Q2G015 Secreted: P02679
Total number of polymer chains	4
Total formula weight	74155.80
Authors	Ganesh, V.K.,Rivera, J.J.,Smeds, E.,Bowden, M.G.,Wann, E.R.,Gurusidappa, S.,Fitzgerald, J.R.,Hook, M. (deposition date: 2008-03-25, release date: 2009-05-19, Last modification date: 2023-12-13)
Primary citation	Ganesh, V.K.,Rivera, J.J.,Smeds, E.,Ko, Y.P.,Bowden, M.G.,Wann, E.R.,Gurusiddappa, S.,Fitzgerald, J.R.,Hook, M. A Structural Model of the Staphylococcus Aureus Clfa-Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics. Plos Pathog., 4:226-, 2008 Cited by PubMed: 19043557 DOI: 10.1371/JOURNAL.PPAT.1000226 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation