2XH1

Crystal structure of human KAT II-inhibitor complex

Summary for 2XH1

Entry DOI	10.2210/pdb2xh1/pdb
Related	2VGZ
Descriptor	KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL, (3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE, PYRIDOXAL-5'-PHOSPHATE, ... (6 entities in total)
Functional Keywords	transferase, covalent inhibition
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion (Potential): Q8N5Z0
Total number of polymer chains	2
Total formula weight	96234.70
Authors	Rossi, F.,Casazza, V.,Garavaglia, S.,Sathyasaikumar, K.V.,Schwarcz, R.,Kojima, S.I.,Okuwaki, K.,Ono, S.I.,Kajii, Y.,Rizzi, M. (deposition date: 2010-06-08, release date: 2010-07-28, Last modification date: 2023-12-20)
Primary citation	Rossi, F.,Casazza, V.,Garavaglia, S.,Sathyasaikumar, K.V.,Schwarcz, R.,Kojima, S.I.,Okuwaki, K.,Ono, S.I.,Kajii, Y.,Rizzi, M. Crystal Structure-Based Selective Targeting of the Pyridoxal 5'-Phsosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement J.Med.Chem., 53:5684-, 2010 Cited by PubMed: 20684605 DOI: 10.1021/JM100464K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation