2XH1
Crystal structure of human KAT II-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL | polymer | 425 | 47398.4 | 2 | UniProt (Q8N5Z0) Pfam (PF00155) | HOMO SAPIENS (HUMAN) | KYNURENINE AMINOTRANSFERASE II, KYNURENINE--OXOGLUTARATE AMINOTRANSFERASE II, KYNURENINE--OXOGLUTARATE TRANSAMINASE II, 2-AMINOADIPATE TRANSAMINASE, 2-AMINOADIPATE AMINOTRANSFERASE, ALPHA-AMINOADIPATE AMINOTRANSFERASE, AADAT |
| 2 | C, F (A, B) | (3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE | non-polymer | 362.4 | 2 | Chemie (BF5) | |||
| 3 | D, G (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 4 | E (A) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 5 | H (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 416 | Chemie (HOH) |
Sequence modifications
A, B: -1 - 425 (UniProt: Q8N5Z0)
| PDB | External Database | Details |
|---|---|---|
| Glu -1 | Met 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 94796.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1438.0 | |
| All* | Total formula weight | 96234.7 |
