2XDW

Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide

2XDW の概要

• エントリーDOI: 10.2210/pdb2xdw/pdb
• 関連するPDBエントリー: 1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3
• 関連するBIRD辞書のPRD_ID: PRD_000694
• 分子名称: Prolyl endopeptidase, SYNTHETIC PEPTIDE PHQ-PRO-YCP, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (5 entities in total)
• 機能のキーワード: alpha/beta-hydrolase, amnesia, beta-propeller, hydrolase, inhibitor
• 由来する生物種: Sus scrofa (pig); 詳細
• 細胞内の位置: Cytoplasm: P23687
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82235.26

構造登録者

Racys, D.T.,Rea, D.,Fulop, V.,Wills, M. (登録日: 2010-05-09, 公開日: 2010-06-23, 最終更新日: 2024-11-06)

主引用文献

Racys, D.T.,Rea, D.,Fulop, V.,Wills, M.
Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide
Bioorg.Med.Chem., 18:4775-, 2010

PubMed Abstract: A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings.

PubMed: 20627594
DOI: 10.1016/J.BMC.2010.05.012

実験手法

X-RAY DIFFRACTION (1.35 Å)