2XBA

Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429

Summary for 2XBA

Related2XB7
DescriptorALK TYROSINE KINASE RECEPTOR, 5-[(2R)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium (3 entities in total)
Functional Keywordsatp-binding, receptor, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane; Single-pass type I membrane protein Q9UM73
Total number of polymer chains1
Total molecular weight35794.14
Authors
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Fogliatto, G.,Bertrand, J.A. (deposition date: 2010-04-08, release date: 2010-07-28, Last modification date: 2011-07-13)
Primary citation
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Avanzi, N.,Borgia, A.L.,Nesi, M.,Bandiera, T.,Fogliatto, G.,Bertrand, J.A.
Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
Biochemistry, 49:6813-, 2010
PubMed: 20695522 (PDB entries with the same primary citation)
DOI: 10.1021/BI1005514
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.182602.0%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2xba
no rotation
Molmil generated image of 2xba
rotated about x axis by 90°
Molmil generated image of 2xba
rotated about y axis by 90°