2XBA
Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK TYROSINE KINASE RECEPTOR | polymer | 315 | 35334.6 | 1 | UniProt (Q9UM73) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, CD246 |
| 2 | B (A) | 5-[(2R)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium | non-polymer | 459.5 | 1 | Chemie (571) | |||
| 3 | C (A) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 1094 - 1407 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1093 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35334.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 459.5 | |
| All* | Total formula weight | 35794.1 |
