2XB7

Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684

Summary for 2XB7

Entry DOI	10.2210/pdb2xb7/pdb
Descriptor	ALK TYROSINE KINASE RECEPTOR, 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE (3 entities in total)
Functional Keywords	atp-binding, receptor, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type I membrane protein: Q9UM73
Total number of polymer chains	1
Total formula weight	35948.82
Authors	Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Fogliatto, G.,Bertrand, J.A. (deposition date: 2010-04-08, release date: 2010-07-28, Last modification date: 2011-07-13)
Primary citation	Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Avanzi, N.,Borgia, A.L.,Nesi, M.,Bandiera, T.,Fogliatto, G.,Bertrand, J.A. Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors. Biochemistry, 49:6813-, 2010 Cited by PubMed: 20695522 DOI: 10.1021/BI1005514 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation