2XB7
Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK TYROSINE KINASE RECEPTOR | polymer | 315 | 35334.6 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, CD246 |
| 2 | A | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE | non-polymer | 614.2 | 1 | Chemie (GUI) | |||
| 3 | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 1094 - 1407 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1093 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35334.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 614.2 | |
| All* | Total formula weight | 35948.8 |
