2X7O
Crystal structure of TGFbRI complexed with an indolinone inhibitor
Summary for 2X7O
Entry DOI | 10.2210/pdb2x7o/pdb |
Related | 1B6C 1IAS 1PY5 1RW8 1VJY 2WOT 2WOU |
Descriptor | TGF-BETA RECEPTOR TYPE I, (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE (2 entities in total) |
Functional Keywords | kinase, transferase, glycoprotein |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 5 |
Total formula weight | 197076.34 |
Authors | Roth, G.J.,Heckel, A.,Brandl, T.,Grauert, M.,Hoerer, S.,Kley, J.T.,Schnapp, G.,Baum, P.,Mennerich, D.,Schnapp, A.,Park, J.E. (deposition date: 2010-03-03, release date: 2010-10-20, Last modification date: 2023-12-20) |
Primary citation | Roth, G.J.,Heckel, A.,Brandl, T.,Grauert, M.,Hoerer, S.,Kley, J.T.,Schnapp, G.,Baum, P.,Mennerich, D.,Schnapp, A.,Park, J.E. Design, Synthesis and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor Beta Receptor I (Tgfbri) J.Med.Chem., 53:7287-, 2010 Cited by PubMed: 20919678DOI: 10.1021/JM100812A PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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