2X7O
Crystal structure of TGFbRI complexed with an indolinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | TGF-BETA RECEPTOR TYPE I | polymer | 342 | 38920.6 | 5 | UniProt (P36897) Pfam (PF08515) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | TGFR-1, TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I, TGF-BETA RECEPTOR TYPE I, TBETAR-I, TGF-BETA TYPE I RECEPTOR, SERINE/THREONINE-PROTEIN KINASE RECEPTOR, R4SKR4, ACTIVIN RECEPTOR-LIKE KINASE 5, ALK-5 |
| 2 | F, G, H, I, J (A, B, C, D, E) | (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE | non-polymer | 494.6 | 5 | Chemie (ZOP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 194603.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2473.1 | |
| All* | Total formula weight | 197076.3 |
