2WOT
ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine
Summary for 2WOT
Entry DOI | 10.2210/pdb2wot/pdb |
Related | 1B6C 1IAS 1PY5 1RW8 1VJY 2WOU |
Descriptor | TGF-BETA RECEPTOR TYPE-1, 4-[(5,6-DIMETHYL-2,2'-BIPYRIDIN-3-YL)OXY]-N-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-2-AMINE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | alk5, kinase, membrane, receptor, manganese, serine/threonine-protein kinase, kinase inhibitor, disease mutation, craniosynostosis, nucleotide-binding, tgf beta type i receptor, phosphoprotein, disulfide bond, aortic aneurysm, glycoprotein, metal-binding, transmembrane, atp-binding, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35459.78 |
Authors | Norman, R.A.,Debreczeni, J.E.,Goldberg, F.W.,Ward, R.A.,Finlay, R.,Powell, S.J.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. (deposition date: 2009-07-28, release date: 2009-09-22, Last modification date: 2024-05-08) |
Primary citation | Goldberg, F.W.,Ward, R.A.,Powell, S.J.,Debreczeni, J.E.,Norman, R.A.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. Rapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5). J.Med.Chem., 52:7901-, 2009 Cited by PubMed: 19736928DOI: 10.1021/JM900807W PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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