2WOT

ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	TGF-BETA RECEPTOR TYPE-1	polymer	306	34939.2	1	UniProt (P36897) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	ALK5, TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I, TGF-BETA RECEPTOR TYPE I, TGF-BETA TYPE I RECEPTOR, TBETAR-I, TGFR-1, SERINE/THREONINE-PROTEIN KINASE RECEPTOR R4, SKR4, ACTIVIN RECEPTOR-LIKE KINASE 5, ALK-5
2	B (A)	4-[(5,6-DIMETHYL-2,2'-BIPYRIDIN-3-YL)OXY]-N-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-2-AMINE	non-polymer		458.5	1	Chemie (ZZG)
3	C (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	D (A)	water	water		18.0	305	Chemie (HOH)

Sequence modifications

A: 198 - 199 (PDB: 2WOT)
A: 200 - 503 (UniProt: P36897)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34939.2
Non-Polymers*	Number of molecules	2
	Total formula weight	520.6
All*	Total formula weight	35459.8

*Water molecules are not included.