2X7D
Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron
Summary for 2X7D
Entry DOI | 10.2210/pdb2x7d/pdb |
Related | 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7E |
Descriptor | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | microtubule, atp-binding, motor protein, cell division, mitosis, inhibitor, cell cycle, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83667.57 |
Authors | Kaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Laggner, C.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F. (deposition date: 2010-02-26, release date: 2010-07-14, Last modification date: 2023-12-20) |
Primary citation | Kaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F. Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53:5676-, 2010 Cited by PubMed: 20597485DOI: 10.1021/JM100421N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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