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2X7D

Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron

Summary for 2X7D
Entry DOI10.2210/pdb2x7d/pdb
Related1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7E
DescriptorKINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsmicrotubule, atp-binding, motor protein, cell division, mitosis, inhibitor, cell cycle, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm: P52732
Total number of polymer chains2
Total formula weight83667.57
Authors
Kaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Laggner, C.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F. (deposition date: 2010-02-26, release date: 2010-07-14, Last modification date: 2023-12-20)
Primary citationKaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F.
Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53:5676-, 2010
Cited by
PubMed: 20597485
DOI: 10.1021/JM100421N
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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