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2X7D

Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron

Functional Information from GO Data
ChainGOidnamespacecontents
A0003777molecular_functionmicrotubule motor activity
A0005524molecular_functionATP binding
A0007018biological_processmicrotubule-based movement
A0008017molecular_functionmicrotubule binding
B0003777molecular_functionmicrotubule motor activity
B0005524molecular_functionATP binding
B0007018biological_processmicrotubule-based movement
B0008017molecular_functionmicrotubule binding
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP A 601
ChainResidue
AARG24
ATHR112
APHE113
AGLU118
AMG1367
AHOH2222
AHOH2278
AHOH2279
AHOH2280
AHOH2281
AHOH2282
AARG26
AHOH2283
AHOH2284
AHOH2285
AHOH2286
APRO27
AGLN106
ATHR107
AGLY108
ATHR109
AGLY110
ALYS111

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1367
ChainResidue
ATHR112
AADP601
AHOH2197
AHOH2222
AHOH2281
AHOH2282

site_idAC3
Number of Residues21
DetailsBINDING SITE FOR RESIDUE ADP B 602
ChainResidue
BARG24
BARG26
BPRO27
BTHR107
BGLY108
BTHR109
BGLY110
BLYS111
BTHR112
BPHE113
BGLU118
BMG1367
BHOH2076
BHOH2182
BHOH2238
BHOH2239
BHOH2240
BHOH2241
BHOH2243
BHOH2244
BHOH2245

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 1367
ChainResidue
BTHR112
BADP602
BHOH2154
BHOH2182
BHOH2239
BHOH2240

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1368
ChainResidue
BSER235
BASP265
BLEU266
BHOH2161
BHOH2183

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1368
ChainResidue
ASER235
AASP265
ALEU266
AHOH2202
AHOH2224

site_idAC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE EGB A 1369
ChainResidue
AGLU116
AGLY117
AGLU118
AARG119
AASP130
AALA133
AILE136
APRO137
ATYR211
AALA218
AHOH2180

site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE EGB B 1369
ChainResidue
BGLU116
BGLY117
BGLU118
BARG119
BTRP127
BASP130
BALA133
BPRO137
BTYR211
BALA218
BHOH2138

Functional Information from PROSITE/UniProt
site_idPS00411
Number of Residues12
DetailsKINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE
ChainResidueDetails
AGLY259-GLU270

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00283
ChainResidueDetails
AGLY105
BGLY105

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS146
BLYS146

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PDB entries from 2024-10-30

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