2X6O

Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline

Summary for 2X6O

Entry DOI	10.2210/pdb2x6o/pdb
Related	1A6I 1BJ0 1BJY 1BJZ 1DU7 1ORK 1QPI 2TCT 2TRT 2VKE 2VKV 2X9D 2XB5 2XGC 2XGD 2XGE 2XPS 2XPT 2XPU 2XPV 2XPW 2XRL
Descriptor	TETRACYCLINE REPRESSOR PROTEIN CLASS D, (4S,4AS,6S,8AS)-6-[(1S)-7-CHLORO-4-HYDROXY-1-METHYL-3-OXO-1,3-DIHYDRO-2-BENZOFURAN-1-YL]-4-(DIMETHYLAMINO)-3,8A-DIHYDROXY-1,8-DIOXO-1,4,4A,5,6,7,8,8A-OCTAHYDRONAPHTHALENE-2-CARBONITRILE, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	transcription, transcription regulation, antibiotic resistance
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	23820.10
Authors	Volkers, G.,Hinrichs, W. (deposition date: 2010-02-18, release date: 2011-03-02, Last modification date: 2023-12-20)
Primary citation	Volkers, G.,Petruschka, L.,Hinrichs, W. Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor. J.Med.Chem., 54:5108-, 2011 Cited by PubMed: 21699184 DOI: 10.1021/JM200332E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation