2X6O

Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2TC A 1209

Chain	Residue
A	HIS64
A	HOH2021
A	ASN82
A	PHE86
A	HIS100
A	VAL113
A	GLN116
A	ILE134
A	SER138
A	HIS139

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1210

Chain	Residue
A	SER74

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1211

Chain	Residue
A	LEU4
A	GLN76
A	ARG80
A	HOH2042

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Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	19
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8153629","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2TRT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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