2X5O

Discovery of Novel 5-Benzylidenerhodanine- and 5-Benzylidene- thiazolidine-2,4-dione Inhibitors of MurD Ligase

2X5O の概要

• エントリーDOI: 10.2210/pdb2x5o/pdb
• 関連するPDBエントリー: 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 3UAG 4UAG
• 分子名称: UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({3-[({4-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENYL}AMINO)METHYL]PHENYL}CARBONYL)-D-GLUTAMIC ACID, AZIDE ION, ... (7 entities in total)
• 機能のキーワード: atp-binding, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase, peptidoglycan synthesis
• 由来する生物種: Escherichia coli DH5[alpha]
• 細胞内の位置: Cytoplasm: P14900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48096.99

構造登録者

Zidar, N.,Tomasic, T.,Sink, R.,Rupnik, V.,Kovac, A.,Turk, S.,Contreras-Martel, C.,Dessen, A.,Blanot, D.,Gobec, S.,Zega, A.,Peterlin-Masic, L.,Kikelja, D. (登録日: 2010-02-10, 公開日: 2010-09-15, 最終更新日: 2023-12-20)

• 主引用文献: Zidar, N.,Tomasic, T.,Sink, R.,Rupnik, V.,Kovac, A.,Turk, S.,Patin, D.,Blanot, D.,Contreras Martel, C.,Dessen, A.,Muller Premru, M.,Zega, A.,Gobec, S.,Peterlin Masic, L.,Kikelj, D.; Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.; J. Med. Chem., 53:6584-6594, 2010; PubMed: 20804196; DOI: 10.1021/jm100285g

実験手法

X-RAY DIFFRACTION (1.46 Å)