2X44

Structure of a strand-swapped dimeric form of CTLA-4

2X44 の概要

• エントリーDOI: 10.2210/pdb2x44/pdb
• 関連するPDBエントリー: 1AH1 1H6E 1I85 1I8L
• 分子名称: CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (2 entities in total)
• 機能のキーワード: immune system, amyloidogenic, systemic lupus erythematosus, immunoglobulin domain, membrane, glycoprotein, transmembrane
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14092.07

構造登録者

Sonnen, A.F.-P.,Yu, C.,Evans, E.J.,Stuart, D.I.,Davis, S.J.,Gilbert, R.J.C. (登録日: 2010-01-28, 公開日: 2010-04-07, 最終更新日: 2024-11-20)

主引用文献

Sonnen, A.F.,Yu, C.,Evans, E.J.,Stuart, D.I.,Davis, S.J.,Gilbert, R.J.C.
Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?
J.Mol.Biol., 399:207-, 2010

PubMed Abstract: We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits.

PubMed: 20394753
DOI: 10.1016/J.JMB.2010.04.011

実験手法

X-RAY DIFFRACTION (2.6 Å)