2X38
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.
Replaces: 2WXESummary for 2X38
Entry DOI | 10.2210/pdb2x38/pdb |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE (3 entities in total) |
Functional Keywords | phosphoinositide 3-kinase, isoform-specific inhibitors, cancer, transferase |
Biological source | MUS MUSCULUS (MOUSE) |
Total number of polymer chains | 1 |
Total formula weight | 108221.10 |
Authors | Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. (deposition date: 2010-01-22, release date: 2010-02-02, Last modification date: 2023-12-20) |
Primary citation | Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol., 6:117-, 2010 Cited by PubMed: 20081827DOI: 10.1038/NCHEMBIO.293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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