2X38

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

Replaces:  2WXE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE IC8 A 2028

Chain	Residue
A	PHE751
A	ASP832
A	THR833
A	MET900
A	ILE910
A	HOH2040
A	MET752
A	PRO758
A	TRP760
A	ILE777
A	ILE825
A	GLU826
A	VAL827
A	VAL828

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Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ

Chain	Residue	Details
A	PHE778-GLN792

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site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN

Chain	Residue	Details
A	SER878-ASN898

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O00329

Chain	Residue	Details
A	TYR524

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:O00329

Chain	Residue	Details
A	SER1039

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