2X2U
First two Cadherin-like domains from Human RET
Summary for 2X2U
Entry DOI | 10.2210/pdb2x2u/pdb |
Related | 1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, UNKNOWN ATOM OR ION, ... (6 entities in total) |
Functional Keywords | hirschsprung disease, extracellular domain, disease mutation, transferase, glycoprotein, transmembrane, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 30071.62 |
Authors | Kjaer, S.,Hanrahan, S.,Purkiss-Trew, A.G.,Totty, N.,McDonald, N.Q. (deposition date: 2010-01-15, release date: 2010-05-19, Last modification date: 2020-07-29) |
Primary citation | Kjaer, S.,Hanrahan, S.,Totty, N.,McDonald, N.Q. Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat. Struct. Mol. Biol., 17:726-731, 2010 Cited by PubMed: 20473317DOI: 10.1038/nsmb.1808 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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