2X2U

First two Cadherin-like domains from Human RET

Summary for 2X2U

Entry DOI	10.2210/pdb2x2u/pdb
Related	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, UNKNOWN ATOM OR ION, ... (6 entities in total)
Functional Keywords	hirschsprung disease, extracellular domain, disease mutation, transferase, glycoprotein, transmembrane, kinase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	30071.62
Authors	Kjaer, S.,Hanrahan, S.,Purkiss-Trew, A.G.,Totty, N.,McDonald, N.Q. (deposition date: 2010-01-15, release date: 2010-05-19, Last modification date: 2020-07-29)
Primary citation	Kjaer, S.,Hanrahan, S.,Totty, N.,McDonald, N.Q. Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat. Struct. Mol. Biol., 17:726-731, 2010 Cited by PubMed: 20473317 DOI: 10.1038/nsmb.1808 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation