2X2U
First two Cadherin-like domains from Human RET
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | polymer | 246 | 28698.5 | 1 | UniProt (P07949) Pfam (PF17756) Pfam (PF00028) In PDB | HOMO SAPIENS (HUMAN) | C-RET, RET, CADHERIN FAMILY MEMBER 12 |
| 2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A | UNKNOWN ATOM OR ION | non-polymer | 11 | Chemie (UNX) | ||||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | A | 1,4-BUTANEDIOL | non-polymer | 90.1 | 2 | Chemie (BU1) | |||
| 6 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 29 - 270 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Arg 87 | Cys 87 | engineered mutation |
| Gln 98 | Asn 98 | engineered mutation |
| Gln 199 | Asn 199 | engineered mutation |
| Ser 216 | Cys 216 | engineered mutation |
| Glu 271 | - | expression tag |
| Phe 272 | - | expression tag |
| Glu 273 | - | expression tag |
| Asn 274 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28698.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 948.7 | |
| All* | Total formula weight | 30071.6 |
