2X2N

X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations

2X2N の概要

• エントリーDOI: 10.2210/pdb2x2n/pdb
• 関連するPDBエントリー: 2WUZ 2WV2 2WX2
• 分子名称: LANOSTEROL 14-ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, p450, metal-binding, methyltransferase, ergosterol biosynthesis
• 由来する生物種: TRYPANOSOMA BRUCEI
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 220475.02

構造登録者

Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (登録日: 2010-01-14, 公開日: 2010-02-02, 最終更新日: 2023-12-20)

• 主引用文献: Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M.; Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole; Plos Negl Trop Dis, 4:E651-, 2010; PubMed: 20386598; DOI: 10.1371/JOURNAL.PNTD.0000651

実験手法

X-RAY DIFFRACTION (2.6 Å)