2WV2

X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole

Summary for 2WV2

• Entry DOI: 10.2210/pdb2wv2/pdb
• Related: 2WUZ 2WX2
• Descriptor: LANOSTEROL 14-ALPHA-DEMETHYLASE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis
• Biological source: TRYPANOSOMA BRUCEI
• Total number of polymer chains: 1
• Total formula weight: 54898.35

Authors

Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-12, release date: 2009-11-10, Last modification date: 2012-05-30)

• Primary citation: Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M.; Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole; Plos Negl Trop Dis, 4:E651-, 2010; PubMed: 20386598; DOI: 10.1371/JOURNAL.PNTD.0000651

Experimental method

X-RAY DIFFRACTION (2.7 Å)