2WV2
X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole
Summary for 2WV2
Entry DOI | 10.2210/pdb2wv2/pdb |
Related | 2WUZ 2WX2 |
Descriptor | LANOSTEROL 14-ALPHA-DEMETHYLASE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis |
Biological source | TRYPANOSOMA BRUCEI |
Total number of polymer chains | 1 |
Total formula weight | 54898.35 |
Authors | Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-12, release date: 2009-11-10, Last modification date: 2024-05-08) |
Primary citation | Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M. Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Plos Negl Trop Dis, 4:E651-, 2010 Cited by PubMed: 20386598DOI: 10.1371/JOURNAL.PNTD.0000651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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