2WV2

X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	LANOSTEROL 14-ALPHA-DEMETHYLASE	polymer	475	53975.6	1	UniProt (Q385E8) Pfam (PF00067)	TRYPANOSOMA BRUCEI	STEROL 14 ALPHA-DEMETHYLASE, CYP51
2	B (A)	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL	non-polymer		306.3	1	Chemie (TPF)
3	C (A)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
4	D (A)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 15 - 21 (PDB: 2WV2)
A: 482 - 489 (PDB: 2WV2)
A: 22 - 481 (UniProt: Q385E8)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53975.6
Non-Polymers*	Number of molecules	2
	Total formula weight	922.8
All*	Total formula weight	54898.4

*Water molecules are not included.