2X2N
X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | LANOSTEROL 14-ALPHA-DEMETHYLASE | polymer | 475 | 53801.5 | 4 | UniProt (Q385E8) Pfam (PF00067) In PDB | TRYPANOSOMA BRUCEI | STEROL 14 ALPHA-DEMETHYLASE, CYP51 |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C, D | POSACONAZOLE | non-polymer | 700.8 | 4 | Chemie (X2N) | |||
4 | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 15 - 21 (PDB: 2X2N)
A, B, C, D: 482 - 489 (PDB: 2X2N)
A, B, C, D: 22 - 481 (UniProt: Q385E8)
A, B, C, D: 482 - 489 (PDB: 2X2N)
A, B, C, D: 22 - 481 (UniProt: Q385E8)
PDB | External Database | Details |
---|---|---|
Ala 249 | Glu 249 | engineered mutation |
Ala 250 | Glu 250 | engineered mutation |
Ala 251 | Glu 251 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 215206.0 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 5269.1 | |
All* | Total formula weight | 220475.0 |