2X2N

X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations

Summary for 2X2N

Entry DOI	10.2210/pdb2x2n/pdb
Related	2WUZ 2WV2 2WX2
Descriptor	LANOSTEROL 14-ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (4 entities in total)
Functional Keywords	oxidoreductase, p450, metal-binding, methyltransferase, ergosterol biosynthesis
Biological source	TRYPANOSOMA BRUCEI
Total number of polymer chains	4
Total formula weight	220475.02
Authors	Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2010-01-14, release date: 2010-02-02, Last modification date: 2023-12-20)
Primary citation	Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M. Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Plos Negl Trop Dis, 4:E651-, 2010 Cited by PubMed: 20386598 DOI: 10.1371/JOURNAL.PNTD.0000651 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation