2WWJ
STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR 10A
Summary for 2WWJ
Entry DOI | 10.2210/pdb2wwj/pdb |
Related | 2GF7 2GFA 2GP3 2GP5 2VD7 |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | chromatin regulator, double-stranded beta helix, oxidoreductase, transcription, oxygenase, host-virus interaction, transcription regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82001.26 |
Authors | Rose, N.R.,Clifton, I.J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-10-23, release date: 2010-03-09, Last modification date: 2023-12-20) |
Primary citation | Rose, N.R.,Woon, E.C.,Kingham, G.L.,King, O.N.,Mecinovic, J.,Clifton, I.J.,Ng, S.S.,Talib-Hardy, J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J. Med. Chem., 53:1810-1818, 2010 Cited by PubMed: 20088513DOI: 10.1021/jm901680b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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