2WWJ

STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR 10A

Summary for 2WWJ

Entry DOI	10.2210/pdb2wwj/pdb
Related	2GF7 2GFA 2GP3 2GP5 2VD7
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywords	chromatin regulator, double-stranded beta helix, oxidoreductase, transcription, oxygenase, host-virus interaction, transcription regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	82001.26
Authors	Rose, N.R.,Clifton, I.J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-10-23, release date: 2010-03-09, Last modification date: 2023-12-20)
Primary citation	Rose, N.R.,Woon, E.C.,Kingham, G.L.,King, O.N.,Mecinovic, J.,Clifton, I.J.,Ng, S.S.,Talib-Hardy, J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J. Med. Chem., 53:1810-1818, 2010 Cited by PubMed: 20088513 DOI: 10.1021/jm901680b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation