2VD7

Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid

Summary for 2VD7

Entry DOI	10.2210/pdb2vd7/pdb
Related	2GF7 2GFA 2GP3 2GP5
Descriptor	JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywords	oxidoreductase, phosphorylation, chromatin regulator, iron, nucleus, zinc-finger, dioxygenase, host-virus interaction, transcription regulation, transcription, metal-binding, histone demethylation inhibitor jmjc domain
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : O75164
Total number of polymer chains	2
Total formula weight	89234.99
Authors	Ng, S.S.,von Delft, F.,Pilka, E.S.,Kavanagh, K.L.,McDonough, M.A.,Savitsky, P.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Schofield, C.J.,Oppermann, U. (deposition date: 2007-10-01, release date: 2007-11-27, Last modification date: 2018-03-28)
Primary citation	Rose, N.R.,Ng, S.S.,Mecinovic, J.,Lienard, B.M.,Bello, S.H.,Sun, Z.,McDonough, M.A.,Oppermann, U.,Schofield, C.J. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J. Med. Chem., 51:7053-7056, 2008 Cited by PubMed: 18942826 DOI: 10.1021/jm800936s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation