2WUZ
X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation
Summary for 2WUZ
Entry DOI | 10.2210/pdb2wuz/pdb |
Related | 2WV2 2WX2 |
Descriptor | LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total) |
Functional Keywords | oxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis |
Biological source | TRYPANOSOMA CRUZI |
Total number of polymer chains | 2 |
Total formula weight | 110087.05 |
Authors | Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-11, release date: 2009-10-20, Last modification date: 2023-12-20) |
Primary citation | Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M. Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Plos Negl Trop Dis, 4:E651-, 2010 Cited by PubMed: 20386598DOI: 10.1371/JOURNAL.PNTD.0000651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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