2WTF

DNA polymerase eta in complex with the cis-diammineplatinum (II) 1,3- GTG intrastrand cross-link

Summary for 2WTF

• Entry DOI: 10.2210/pdb2wtf/pdb
• Related: 1JIH 2XGP 2XGQ
• Descriptor: DNA POLYMERASE ETA, 5'-D(*TP*CP*TP*TP*CP*TP*GP*TP*GP*CP *TP*CP*AP*CP*CP*AP*CP)-3', 5'-D(*GP*TP*GP*GP*TP*GP*AP*GP*CP)-3', ... (7 entities in total)
• Functional Keywords: transferase-dna complex, nucleotidyltransferase, translesion dna synthesis, transferase, dna-binding, dna synthesis, dna replication, mutator protein, dna damage, dna repair, transferase/dna
• Biological source: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• Cellular location: Nucleus: Q04049
• Total number of polymer chains: 6
• Total formula weight: 139202.82

Authors

Reissner, T.,Schneider, S.,Ziv, O.,Schorr, S.,Livneh, Z.,Carell, T. (deposition date: 2009-09-16, release date: 2010-03-31, Last modification date: 2023-12-20)

• Primary citation: Reissner, T.,Schneider, S.,Schorr, S.,Carell, T.; Crystal Structure of a Cisplatin-(1,3-Gtg) Cross-Link within DNA Polymerase Eta.; Angew.Chem.Int.Ed.Engl., 49:3077-, 2010; PubMed: 20333640; DOI: 10.1002/ANIE.201000414

Experimental method

X-RAY DIFFRACTION (2.5 Å)