2WOQ

Porphobilinogen Synthase (HemB) in Complex with 5-acetamido-4- oxohexanoic acid (Alaremycin 2)

Summary for 2WOQ

Entry DOI	10.2210/pdb2woq/pdb
Related	1B4K 1GZG 1W54 1W56 1W5M 1W5N 1W5O 1W5P 1W5Q 2C13 2C14 2C15 2C16 2C18 2C19
Descriptor	DELTA-AMINOLEVULINIC ACID DEHYDRATASE, ALAREMYCIN 2, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	lyase-antibiotic complex, lyase antibiotic complex, metal-binding, heme biosynthesis, porphyrin biosynthesis, porpobilinogen synthase, hemb, lyase, inhibitor, lyase/antibiotic
Biological source	PSEUDOMONAS AERUGINOSA
Total number of polymer chains	1
Total formula weight	39432.90
Authors	Heinemann, I.U.,Schulz, C.,Schubert, W.-D.,Heinz, D.W.,Wang, Y.-G.,Kobayashi, Y.,Awa, Y.,Wachi, M.,Jahn, D.,Jahn, M. (deposition date: 2009-07-27, release date: 2009-10-27, Last modification date: 2023-12-20)
Primary citation	Heinemann, I.U.,Schulz, C.,Schubert, W.D.,Heinz, D.W.,Wang, Y.G.,Kobayashi, Y.,Awa, Y.,Wachi, M.,Jahn, D.,Jahn, M. Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob. Agents Chemother., 54:267-272, 2010 Cited by PubMed: 19822707 DOI: 10.1128/AAC.00553-09 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation