2C16

5-(4-Carboxy-2-oxo-butane-1-sulfinyl)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa

Summary for 2C16

• Entry DOI: 10.2210/pdb2c16/pdb
• Related: 1B4K 1GZG 1W54 1W56 1W5M 1W5N 1W5O 1W5P 1W5Q 2C13 2C14 2C15 2C18 2C19
• Descriptor: DELTA-AMINOLEVULINIC ACID DEHYDRATASE, MAGNESIUM ION, TRIETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: enzyme mechanism, metalloenzyme, porphobilinogen synthase, cocrystallization, lyase, magnesium, metal-binding, porphyrin biosynthesis
• Biological source: PSEUDOMONAS AERUGINOSA
• Total number of polymer chains: 2
• Total formula weight: 75317.07

Authors

Frere, F.,Nentwich, M.,Gacond, S.,Heinz, D.W.,Neier, R.,Frankenberg-Dinkel, N. (deposition date: 2005-09-11, release date: 2006-06-20, Last modification date: 2023-12-13)

• Primary citation: Frere, F.,Nentwich, M.,Gacond, S.,Heinz, D.W.,Neier, R.,Frankenberg-Dinkel, N.; Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors.; Biochemistry, 45:8243-, 2006; PubMed: 16819823; DOI: 10.1021/BI052611F

Experimental method

X-RAY DIFFRACTION (2.02 Å)