complete extracellular structure of human signal regulatory protein (SIRP) alpha

Summary for 2WNG

Related2JJT 2UV3 2JJS
DescriptorTYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywordssignal regulatory protein alpha, immunoglobulin superfamily, phosphoprotein, disulfide bond, paired receptor, alternative splicing, immunoglobulin domain, sirp, cd47, sirpa, membrane, sh3-binding, polymorphism, glycoprotein, transmembrane, cell adhesion
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight36425.54
Hatherley, D.,Graham, S.C.,Harlos, K.,Stuart, D.I.,Barclay, A.N. (deposition date: 2009-07-09, release date: 2009-07-21, Last modification date: 2020-07-29)
Primary citation
Hatherley, D.,Graham, S.C.,Harlos, K.,Stuart, D.I.,Barclay, A.N.
Structure of Signal-Regulatory Protein Alpha: A Link to Antigen Receptor Evolution.
J.Biol.Chem., 284:26613-, 2009
PubMed: 19628875 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M109.017566
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28690 1.9% 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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