2WNG

complete extracellular structure of human signal regulatory protein (SIRP) alpha

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0009986cellular_componentcell surface
A0070062cellular_componentextracellular exosome
A0101003cellular_componentficolin-1-rich granule membrane
A0005887cellular_componentintegral component of plasma membrane
A0016020cellular_componentmembrane
A0005886cellular_componentplasma membrane
A0070821cellular_componenttertiary granule membrane
A0098632molecular_functioncell-cell adhesion mediator activity
A0030695molecular_functionGTPase regulator activity
A1990405molecular_functionprotein antigen binding
A0086080molecular_functionprotein binding involved in heterotypic cell-cell adhesion
A0019903molecular_functionprotein phosphatase binding
A1990782molecular_functionprotein tyrosine kinase binding
A0017124molecular_functionSH3 domain binding
A0007155biological_processcell adhesion
A0016477biological_processcell migration
A0070301biological_processcellular response to hydrogen peroxide
A0071346biological_processcellular response to interferon-gamma
A0071347biological_processcellular response to interleukin-1
A0071349biological_processcellular response to interleukin-12
A0071222biological_processcellular response to lipopolysaccharide
A0050900biological_processleukocyte migration
A0035696biological_processmonocyte extravasation
A0071650biological_processnegative regulation of chemokine (C-C motif) ligand 5 production
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A1903720biological_processnegative regulation of I-kappaB phosphorylation
A0050728biological_processnegative regulation of inflammatory response
A0032688biological_processnegative regulation of interferon-beta production
A0032715biological_processnegative regulation of interleukin-6 production
A0046329biological_processnegative regulation of JNK cascade
A0071641biological_processnegative regulation of macrophage inflammatory protein 1 alpha production
A0045019biological_processnegative regulation of nitric oxide biosynthetic process
A0050765biological_processnegative regulation of phagocytosis
A0001933biological_processnegative regulation of protein phosphorylation
A0032720biological_processnegative regulation of tumor necrosis factor production
A0043312biological_processneutrophil degranulation
A0022409biological_processpositive regulation of cell-cell adhesion
A0050766biological_processpositive regulation of phagocytosis
A0050870biological_processpositive regulation of T cell activation
A0010468biological_processregulation of gene expression
A0032649biological_processregulation of interferon-gamma production
A0032651biological_processregulation of interleukin-1 beta production
A0032675biological_processregulation of interleukin-6 production
A0045428biological_processregulation of nitric oxide biosynthetic process
A0032680biological_processregulation of tumor necrosis factor production
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC17BINDING SITE FOR RESIDUE NAG A 1239
ChainResidue
AASN80
ATHR82
AGLN230
AASN239
ATHR241
AMET282
ATRP284

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
NAG_2wng_A_12396N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AGLN230NAG: N-ACETYL-D-GLUCOSAMINE
AASN239NAG: N-ACETYL-D-GLUCOSAMINE
ATHR241NAG: N-ACETYL-D-GLUCOSAMINE
AMET282NAG: N-ACETYL-D-GLUCOSAMINE
ATRP284NAG: N-ACETYL-D-GLUCOSAMINE
ALEU286NAG: N-ACETYL-D-GLUCOSAMINE

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails