2WHP

Crystal structure of acetylcholinesterase, phosphonylated by sarin and in complex with HI-6

Summary for 2WHP

• Entry DOI: 10.2210/pdb2whp/pdb
• Related: 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JEZ 2JF0 2JGE 2JGF 2JGG 2JGH 2JGI 2JGJ 2JGK 2JGL 2JGM 2WHQ 2WHR
• Descriptor: ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM, ... (8 entities in total)
• Functional Keywords: serine esterase, alternative splicing, neurotransmitter degradation, hi-6, sarin, synapse, membrane, secreted, hydrolase, cell membrane, disulfide bond, cholinesterase, gpi-anchor, lipoprotein, glycoprotein, cell junction
• Biological source: MUS MUSCULUS (MOUSE); More
• Total number of polymer chains: 2
• Total formula weight: 122383.79

Authors

Ekstrom, F.,Hornberg, A.,Artursson, E.,Hammarstrom, L.G.,Schneider, G.,Pang, Y.P. (deposition date: 2009-05-06, release date: 2009-06-30, Last modification date: 2023-12-13)

• Primary citation: Ekstrom, F.,Hornberg, A.,Artursson, E.,Hammarstrom, L.G.,Schneider, G.,Pang, Y.P.; Structure of Hi-6Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design.; Plos One, 4:E5957-, 2009; PubMed: 19536291; DOI: 10.1371/JOURNAL.PONE.0005957

Experimental method

X-RAY DIFFRACTION (2.2 Å)