2WHP
Crystal structure of acetylcholinesterase, phosphonylated by sarin and in complex with HI-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ACETYLCHOLINESTERASE | polymer | 548 | 60354.1 | 1 | UniProt (P21836) Pfam (PF00135) | MUS MUSCULUS (MOUSE) | ACHE |
| 2 | B (B) | ACETYLCHOLINESTERASE | polymer | 548 | 60341.0 | 1 | UniProt (P21836) Pfam (PF00135) | MUS MUSCULUS (MOUSE) | ACHE |
| 3 | C, D, G (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | E, H (A, B) | 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM | non-polymer | 288.3 | 2 | Chemie (HI6) | |||
| 5 | F (A) | CARBONATE ION | non-polymer | 60.0 | 1 | Chemie (CO3) | |||
| 6 | I (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | J (B) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 8 | K, L (A, B) | water | water | 18.0 | 793 | Chemie (HOH) |
Sequence modifications
A: 1 - 542 (UniProt: P21836)
A: 543 - 548 (PDB: 2WHP)
B: 1 - 542 (UniProt: P21836)
B: 543 - 548 (PDB: 2WHP)
A: 543 - 548 (PDB: 2WHP)
B: 1 - 542 (UniProt: P21836)
| PDB | External Database | Details |
|---|---|---|
| Asp 499 | Gln 531 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 120695.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1688.7 | |
| All* | Total formula weight | 122383.8 |
