2WCO

Structures of the Streptomyces coelicolor A3(2) Hyaluronan Lyase in Complex with Oligosaccharide Substrates and an Inhibitor

Summary for 2WCO

Entry DOI	10.2210/pdb2wco/pdb
Related	2WDA 2X03
Descriptor	PUTATIVE SECRETED LYASE, 4-deoxy-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (5 entities in total)
Functional Keywords	lyase, family 8, glycosaminoglycans (gags) hydrolysis
Biological source	STREPTOMYCES COELICOLOR A3(2)
Total number of polymer chains	1
Total formula weight	83587.71
Authors	Elmabrouk, Z.H.,Taylor, E.J.,Vincent, F.,Smith, N.L.,Zhang, M.,Charnock, S.J.,Turkenburg, J.P.,Davies, G.J.,Black, G.W. (deposition date: 2009-03-12, release date: 2010-08-18, Last modification date: 2020-07-29)
Primary citation	Elmabrouk, Z.H.,Vincent, F.,Zhang, M.,Smith, N.L.,Turkenburg, J.P.,Charnock, S.J.,Black, G.W.,Taylor, E.J. Crystal Structures of a Family 8 Polysaccharide Lyase Reveal Open and Highly Occluded Substrate-Binding Cleft Conformations. Proteins, 79:965-, 2011 Cited by PubMed: 21287626 DOI: 10.1002/PROT.22938 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation