2WA3
FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-hydroxyphenyl)-2-oxoacetic acid
Summary for 2WA3
Entry DOI | 10.2210/pdb2wa3/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA4 |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID, ... (4 entities in total) |
Functional Keywords | hydroxylase, dioxygenase, transcription, oxidoreductase, transcription activator/inhibitor, hypoxia |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: Q9NWT6 |
Total number of polymer chains | 1 |
Total formula weight | 40550.26 |
Authors | Conejo-Garcia, A.,Lienard, B.M.R.,Clifton, I.J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-02-02, release date: 2010-04-21, Last modification date: 2023-12-13) |
Primary citation | Conejo-Garcia, A.,McDonough, M.A.,Loenarz, C.,McNeill, L.A.,Hewitson, K.S.,Ge, W.,Lienard, B.M.,Schofield, C.J.,Clifton, I.J. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20:6125-6128, 2010 Cited by PubMed: 20822901DOI: 10.1016/j.bmcl.2010.08.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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